1,2-cyclic sulfamidates as versatile precursors to thiomorpholines and piperazines

被引：62

作者：

Williams, AJ

Chakthong, S

Gray, D

Lawrence, RM

Gallagher, T

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] GlaxoSmithKline, Med Res Ctr, Chem Dev, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 06期

关键词：

D O I：

10.1021/ol027418h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Graphics 1,2-Cyclic sulfamidates undergo regiospecific nucleophilic displacement with either methyl thioglycolate or a-amino esters, followed by lactamization (thermal, base-mediated, or cyanide-catalyzed), to give thiomorpholin-3-ones and piperazin-2-ones.

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收藏

页码：811 / 814

页数：4

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