Mortality and causes of death in persons with Down syndrome in California

被引：137

作者：

Day, SM ^{[1
]}

Strauss, DJ ^{[1
]}

Shavelle, RM ^{[1
]}

Reynolds, RJ ^{[1
]}

机构：

[1] Life Expectancy Project, San Francisco, CA 94122 USA

来源：

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | 2005年 / 47卷 / 03期

关键词：

D O I：

10.1017/S0012162205000319

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study investigated mortality and causes of death between 1988 and 1999 in 14 781 persons (6702 female) with Down syndrome in California, comparing age, sex, ethnicity, and other factors. Mean age at the start of follow-up was 14 years 8 months (SD 14y 10mo). During the study period 600 persons died. The standardized mortality ratio (SMR) for the population was 5.5. Blacks were at greater risk than whites, Hispanics, or Asians (relative risk=1.5). Mortality declined during the period, especially for children with congenital heart defects. Leukemia (SMR=17), respiratory illnesses (SMR=27), congenital anomalies (SMR=72), and circulatory diseases (SMR=5.3) accounted for most of the excess mortality. With the exception of leukemia, cancer mortality was not different from that of the general population.

引用

页码：171 / 176

页数：6

共 34 条

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