DNA damage checkpoints update: getting molecular

被引：171

作者：

Weinert, T ^{[1
]}

机构：

[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(98)80140-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic checkpoint controls impose delays in the cell cycle in response to DNA damage or defects in DNA replication. Genetic and physiological studies in budding yeast have identified key genes and defined genetic pathways involved in checkpoint-mediated responses. Recent studies now lead to biochemical models that explain at least in part the arrest in GI and delays during DNA replication after damage. Though progress in checkpoint controls has indeed been rapid, several observations identify puzzling aspects of checkpoint controls with few plausible explanations. (C) Current Biology Ltd ISSN 0959-437X.

引用

页码：185 / 193

页数：9

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