Decreased risk of stroke in patients receiving traditional Chinese medicine for vertigo: A population-based cohort study

被引：31

作者：

Tsai, Tzung-Yi ^{[1
,2
,3
]}

Li, Chung-Yi ^{[4
,5
]}

Livneh, Hanoch ^{[6
]}

Lin, I-Hsin ^{[7
]}

Lu, Ming-Chi ^{[8
,9
]}

Yeh, Chia-Chou ^{[7
,10
]}

机构：

[1] Buddhist Tzuchi Med Fdn, Dalin Tzuchi Hosp, Dept Med Res, 2 Minsheng Rd, Chiayi 62247, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, 138 Sheng Li Rd, Tainan 70428, Taiwan

[3] Tzu Chi Coll Technol, Dept Nursing, 880 Chien Kuo Rd Sect 2, Hualien 97004, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, 138 Sheng Li Rd, Tainan 70428, Taiwan

[5] China Med Univ, Coll Publ Hlth, Dept Publ Hlth, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

[6] Portland State Univ, Rehabil Counseling Program, Portland, OR 97207 USA

[7] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, 701 Jhongyang Rd Sect 3, Hualien 97004, Taiwan

[8] Buddhist Tzuchi Med Fdn, Dalin Tzuchi Hosp, Div Allergy Immunol & Rheumatol, 2 Minsheng Rd, Chiayi 62247, Taiwan

[9] Tzu Chi Univ, Sch Med, 701 Jhongyang Rd Sect 3, Hualien 97004, Taiwan

[10] Buddhist Tzuchi Med Fdn, Dalin Tzuchi Hosp, Dept Chinese Med, 2 Minsheng Rd, Chiayi 62247, Taiwan

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2016年 / 184卷

关键词：

Cohort study; Stroke; Traditional Chinese medicine; Vertigo; HERBAL PRODUCTS; BREAST-CANCER; TAIWAN; ISCHEMIA; CARE;

D O I：

10.1016/j.jep.2016.03.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Ethnopharmacological relevance: Patients with vertigo are reported to exhibit a higher risk of subsequent stroke. However, it remains unclear if Traditional Chinese Medicine (TCM), the most common form of complementary and alternative medicine, can help lower the risk of stroke for these patients. So the aim of the study was to investigate the effects of TCM on stroke risk among patients with vertigo. Materials and methods: This longitudinal cohort study used the Taiwanese National Health Insurance Research Database to identify 112,458 newly diagnosed vertigo patients aged >= 20 years who received treatment between 1998 and 2007. Among these patients, 53,203 (47.31%) received TCM after vertigo onset (TCM users), and the remaining 59,201 patients were designated as a control group (non-TCM users). All enrollees received follow-up until the end of 2012 to measure stroke incidence. Cox proportional hazards regression was used to compute the hazard ratio (HR) of stroke in recipients of TCM services. Results: During 15-year follow-up, 5532 TCM users and 12,295 non-TCM users developed stroke, representing an incidence rate of 13.10% and 25.71% per 1000 person-years. TCM users had a significantly reduced risk of stroke compared to non TCM users (adjusted HR=0.64; 95% confidence interval CI=0.59-0.74). The predominant effect was observed for those receiving TCM for more than 180 days (adjusted HR=0.52; 95% CI=0.49-0.56). Commonly used TCM formulae, including Ban-Xia-Bai-Zhu-Tian-Ma-Tang, Ling-Gui-Zhu-Gan-Tang, Bai Zhi (Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Say., root), Ge Gen (Pueraria lobata (Willd.) Ohwi, root) and Hai Piao Xiao (Endoconcha Sepiae, Cuttlefish Bone) were significantly associated with lower risk of stroke. Conclusions: Results of this population-based study support the effects of TCM on reducing stroke risk, and may provide a reference for stroke prevention strategies. The study results may also help to integrate TCM into clinical intervention programs that provide a favorable prognosis for vertigo patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：138 / 143

页数：6

共 33 条

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Colocalization of 5-HT1F receptor and glutamate in neurons of the vestibular nuclei in rats [J].