Data integration: Challenges for drug discovery

被引:126
作者
Searls, DB [1 ]
机构
[1] GlaxoSmithKline, Bioinformat Div, Genet Res, King Of Prussia, PA 19406 USA
关键词
D O I
10.1038/nrd1608
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The effective integration of data and knowledge from many disparate sources will be crucial to future drug discovery. Data integration is a key element of conducting scientific investigations with modern platform technologies, managing increasingly complex discovery portfolios and processes, and fully realizing economies of scale in large enterprises. However, viewing data integration as simply an 'IT problem' underestimates the novel and serious scientific and management challenges it embodies - challenges that could require significant methodological and even cultural changes in our approach to data.
引用
收藏
页码:45 / 58
页数:14
相关论文
共 175 条
[1]   CRASP: a program for analysis of coordinated substitutions in multiple alignments of protein sequences [J].
Afonnikov, DA ;
Kolchanov, NA .
NUCLEIC ACIDS RESEARCH, 2004, 32 :W64-W68
[2]   Inventories to insights [J].
Aitchison, JD ;
Galitski, T .
JOURNAL OF CELL BIOLOGY, 2003, 161 (03) :465-469
[3]   FatiGO:: a web tool for finding significant associations of Gene Ontology terms with groups of genes [J].
Al-Shahrour, F ;
Díaz-Uriarte, R ;
Dopazo, J .
BIOINFORMATICS, 2004, 20 (04) :578-580
[4]   Biological networks [J].
Alm, E ;
Arkin, AP .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2003, 13 (02) :193-202
[5]  
[Anonymous], 1961, Adaptive Control Processes: a Guided Tour, DOI DOI 10.1515/9781400874668
[6]  
[Anonymous], 1986, INTRO MODAL LOGIC
[7]  
Ashburner M, 2002, NOVART FDN SYMP, V247, P66
[8]   Analyzing yeast protein-protein interaction data obtained from different sources [J].
Bader, GD ;
Hogue, CWV .
NATURE BIOTECHNOLOGY, 2002, 20 (10) :991-997
[9]   Transitions still to be made [J].
Ball, P .
NATURE, 1999, 402 (6761) :C73-C76
[10]   Network biology:: Understanding the cell's functional organization [J].
Barabási, AL ;
Oltvai, ZN .
NATURE REVIEWS GENETICS, 2004, 5 (02) :101-U15