Data integration: Challenges for drug discovery

被引：126

作者：

Searls, DB ^{[1
]}

机构：

[1] GlaxoSmithKline, Bioinformat Div, Genet Res, King Of Prussia, PA 19406 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 01期

关键词：

D O I：

10.1038/nrd1608

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effective integration of data and knowledge from many disparate sources will be crucial to future drug discovery. Data integration is a key element of conducting scientific investigations with modern platform technologies, managing increasingly complex discovery portfolios and processes, and fully realizing economies of scale in large enterprises. However, viewing data integration as simply an 'IT problem' underestimates the novel and serious scientific and management challenges it embodies - challenges that could require significant methodological and even cultural changes in our approach to data.

引用

页码：45 / 58

页数：14

共 175 条

[41] Cluster analysis and display of genome-wide expression patterns [J].

Eisen, MB ;

Spellman, PT ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868

[42] Discovering novel cis-regulatory motifs using functional networks [J].

Ettwiller, LM ;

Rung, J ;

Birney, E .

GENOME RESEARCH, 2003, 13 (05) :883-895

[43]

FARIN GE, 2003, HIERARCHICAL GEOMETR

[44]

Ficenec David, 2003, Briefings in Bioinformatics, V4, P260, DOI 10.1093/bib/4.3.260

[45] 2HAPI: a microarray data analysis system [J].

Fink, JL ;

Drewes, S ;

Patel, H ;

Welsh, JB ;

Masys, DR ;

Corbeil, J ;

Gribskov, MR .

BIOINFORMATICS, 2003, 19 (11) :1443-1445

[46]

Gault LV, 2002, J MED LIBR ASSOC, V90, P173

[47] Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast [J].

Giaever, G ;

Flaherty, P ;

Kumm, J ;

Proctor, M ;

Nislow, C ;

Jaramillo, DF ;

Chu, AM ;

Jordan, MI ;

Arkin, AP ;

Davis, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (03) :793-798

[48] Advances in high content screening for drug discovery [J].

Giuliano, KA ;

Haskins, JR ;

Taylor, DL .

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2003, 1 (04) :565-577

[49] Statistical themes and lessons for data mining [J].

Glymour, C ;

Madigan, D ;

Pregibon, D ;

Smyth, P .

DATA MINING AND KNOWLEDGE DISCOVERY, 1997, 1 (01) :11-28

[50]

GOLDEN J, 2003, CURR DRUG DISCOV FEB, P17

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