Time dependent alterations in dopamine tissue levels and metabolism after experimental traumatic brain injury in rats

被引：66

作者：

Massucci, JL

Kline, AE

Ma, XC

Zafonte, RD

Dixon, CE ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Brain Trauma Res Ctr, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA USA

[4] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA USA

来源：

NEUROSCIENCE LETTERS | 2004年 / 372卷 / 1-2期

关键词：

catecholamine; CCI; DOPAC; dopamine; TBI;

D O I：

10.1016/j.neulet.2004.09.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several studies have demonstrated alterations in the dopamine (DA) system after traumatic brain injury (TBI). The present study investigated the temporal changes in DA tissue levels and metabolism at 1-h or 1, 7, 14, and 28 days after cortical impact or sham injury in rats. DA and DOPAC levels were measured by HPLC in the frontal cortex (FC) and striatum. DA levels were significantly increased at 1 h in the contralateral FC and at 1 day in the ipsilateral FC versus respective sham groups. DA and DOPAC levels were significantly increased bilaterally at 1 h in the striatum versus sham. These data indicate that TBI induces an early increase in DA and DOPAC, which returns to sham levels over time. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：127 / 131

页数：5

共 23 条

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