From top to bottom: midkine and pleiotrophin as emerging players in immune regulation

被引：72

作者：

Sorrelle, Noah ^{[1
]}

Dominguez, Adrian T. A. ^{[1
]}

Brekken, Rolf A. ^{[1
,2
,3
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, 6000 Harry Hines Blvd, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Div Surg Oncol, Dept Surg, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Div Surg Oncol, Dept Pharmacol, Dallas, TX 75390 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2017年 / 102卷 / 02期

基金：

美国国家卫生研究院;

关键词：

hematopoiesis; myeloid cells; lymphoid cells; cytokines; ANAPLASTIC LYMPHOMA KINASE; GROWTH-FACTOR MIDKINE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TYROSINE-PHOSPHATASE-BETA/ZETA; IMMUNODEFICIENCY-VIRUS TYPE-1; HEPARIN-BINDING CYTOKINES; GENE-EXPRESSION; UP-REGULATION; HB-GAM; MACROPHAGE INFILTRATION;

D O I：

10.1189/jlb.3MR1116-475R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.

引用

页码：277 / 286

页数：10

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