Interpreting composite outcomes in trials

被引:16
作者
Freemantle, Nick [1 ]
Calvert, Melanie J. [1 ]
机构
[1] Univ Birmingham, Sch Hlth & Populat Sci, Birmingham B15 2SP, England
来源
BRITISH MEDICAL JOURNAL | 2010年 / 341卷
基金
英国医学研究理事会;
关键词
CLINICAL-TRIALS; END-POINTS; RANDOMIZED-TRIALS;
D O I
10.1136/bmj.c3529
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 12 条
[1]  
[Anonymous], 1998, ICH HARM TRIP GUID S
[2]   Empirical evidence for selective reporting of outcomes in randomized trials -: Comparison of Protocols to published articles [J].
Chan, AW ;
Hróbjartsson, A ;
Haahr, MT ;
Gotzsche, PC ;
Altman, DG .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (20) :2457-2465
[3]   Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review [J].
Cordoba, Gloria ;
Schwartz, Lisa ;
Woloshin, Steven ;
Bae, Harold ;
Gotzsche, Peter C. .
BMJ-BRITISH MEDICAL JOURNAL, 2010, 341 :381
[4]   Composite endpoints in clinical trials:: the trees and the forest [J].
Ferreira-Gonzalez, Ignacio ;
Permanyer-Miralda, Gaieta ;
Busse, Jason W. ;
Bryant, Dianne M. ;
Montori, Victor M. ;
Alonso-Coello, Pablo ;
Walter, Stephen D. ;
Guyatt, Gordon H. .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2007, 60 (07) :660-661
[5]   Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns [J].
Ferreira-Gonzalez, Ignacio ;
Permanyer-Miralda, Gaieta ;
Busse, Jason W. ;
Bryant, Dianne M. ;
Montori, Victor M. ;
Alonso-Coello, Pablo ;
Walter, Stephen D. ;
Guyatt, Gordon H. .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2007, 60 (07) :651-657
[6]   Composite outcomes in randomized trials - Greater precision but with greater uncertainty? [J].
Freemantle, N ;
Calvert, M ;
Wood, J ;
Eastaugh, J ;
Griffin, C .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (19) :2554-2559
[7]   Interpreting the results of secondary end points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic? [J].
Freemantle, N .
BRITISH MEDICAL JOURNAL, 2001, 322 (7292) :989-991
[8]   Weighing the pros and cons for composite outcomes in clinical trials [J].
Freemantle, Nick ;
Calvert, Melanie .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2007, 60 (07) :658-659
[9]   Effect of Dronedarone on Cardiovascular Events in Atrial Fibrillation [J].
Hohnloser, Stefan H. ;
Crijns, Harry J. G. M. ;
van Eickels, Martin ;
Gaudin, Christophe ;
Page, Richard L. ;
Torp-Pedersen, Christian ;
Connolly, Stuart J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (07) :668-678
[10]   Validity of composite end points in clinical trials [J].
Montori, VM ;
Permanyer-Miralda, G ;
Ferreira-González, I ;
Busse, JW ;
Pacheco-Huergo, V ;
Bryant, D ;
Alonso, J ;
Akl, EA ;
Domingo-Salvany, A ;
Mills, E ;
Wu, P ;
Schünemann, HJ ;
Jaeschke, R ;
Guyatt, GH .
BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7491) :594-596