Stereochemical and skeletal diversity employing pipecolate ester scaffolds

被引：18

作者：

Chen, Yu

Porco, John A., Jr.

Panek, James S.

机构：

[1] Boston Univ, Dept Chem, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA

[2] Boston Univ, Ctr Chem Methodol & Lib Dev, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 08期

关键词：

D O I：

10.1021/ol070321g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The stereocontrolled synthesis of pyridooxazinones by Mg(OTf)(2)-promoted epoxide ring-opening with use of chiral pipecolates as nucleophiles is described. Pyridooxazinone products derived from azido-epoxides can be further rearranged to seven-membered pyridodiazepinones by azide reduction. The sequence of functional group interconversions generates diversity through topological and stereochemical variation.

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页码：1529 / 1532

页数：4

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