Cell-cycle signaling: Atm displays its many talents

被引：39

作者：

Westphal, CH ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02115

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(06)00406-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of multiple signaling cascades downstream of Atm may lead to a clearer understanding of the diverse defects seen in ataxia telangiectasia. These pathways - which include evolutionarily conserved Chk1 and Atr, and non-conserved p21, p53 and Abl - guard genomic integrity after DNA damage.

引用

页码：R789 / R792

页数：4

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