Protective effects of fullerenol on carbon tetrachloride-induced acute hepatotoxicity and nephrotoxicity in rats

被引：72

作者：

Xu, Jing-Ying ^{[1
,2
,3
]}

Su, Yuan-Yuan ^{[3
,4
]}

Cheng, Jin-Sheng ^{[5
]}

Li, Shu-Xia ^{[6
]}

Liu, Ruili ^{[3
]}

Li, Wen-Xin ^{[3
]}

Xu, Guo-Tong ^{[1
,2
]}

Li, Qing-Nuan ^{[3
]}

机构：

[1] Tongji Univ, Sch Med, Tongji Eye Inst, Lab Clin Visual Sci, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Med, Dept Regenerat Med, Shanghai 200092, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China

[4] Nanjing Univ, Dept Biochem, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[5] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[6] Tongji Univ, Sch Med, Affiliated Matern & Infant Hlth Hosp 1, Dept Pathol, Shanghai 200040, Peoples R China

来源：

CARBON | 2010年 / 48卷 / 05期

基金：

中国国家自然科学基金;

关键词：

RADICAL SCAVENGING ACTIVITY; SPRAGUE-DAWLEY RATS; HEPATIC GLUTATHIONE; LIPID-PEROXIDATION; MALIGNANT NEOPLASM; OXIDATIVE STRESS; C-60(OH)(24); TOXICITY; BIODISTRIBUTION; DAMAGE;

D O I：

10.1016/j.carbon.2009.12.029

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

An important biologically-relevant property of fullerenol. is its ability to quench free radicals Carbon tetrachloride (CCl4)-induced hepatotoxicity and nephrotoxicity model was used to investigate the possible mechanisms of fullerenol protection in Sprague-Dawley rats in this study Rats were administrated with fullerenol (0, 1, 15 and 5 mg/kg d) by intravenous or intraperitoneal injection for 3 days before CCl4 challenge, 24 h following the CCl4 challenge, all the rats were assessed using serum and tissue homogenates biomarkers as well as the pathological evaluation All results showed that CCl4 caused significant increasing serum activity of alanine aminotransferase and aspartate aminotransferase, as well as the concentration of blood urea nitrogen and creatinine Malondialdehyde level was also increased significantly, whereas the ratio of reduced glutathione to oxidized glutathione was decreased in tissue homogenates The pathological evaluation indicated the liver and kidney were damaged by CCl4 Fullerenol-pretreatment alleviated biomarker changes as well as histological changes significantly, and fullerenol-pretreatment alone can increase the ratio of reduced glutathione to oxidized glutathione, which indicated fullerenol could protect tissues against CCl4-induced oxidative stress by improving the antioxidant ability (C) 2010 Elsevier Ltd All rights reserved

引用

页码：1388 / 1396

页数：9

共 35 条

[1]

Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication [J].