Patterns of brain acetylcholine release predict individual differences in preferred learning strategies in rats

被引:93
作者
McIntyre, CK
Marriott, LK
Gold, PE
机构
[1] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA
[2] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
[3] Univ Arizona, Div Neural Syst Memory & Aging, Arizona Res Labs, Tucson, AZ 85724 USA
关键词
acetylcholine; learning strategies; memory modulation; hippocampus; striatum; place learning; spatial learning; response learning;
D O I
10.1016/S1074-7427(02)00014-X
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Acetylcholine release was measured simultaneously in the hippocampus and dorsal striatum of rats before and during training on a maze that could be learned using either a hippocampus-dependent spatial strategy or a dorsal striatum-dependent turning strategy. A probe trial administered after rats reached a criterion of 9/10 correct responses revealed that about half of the rats used a spatial strategy and half a turning strategy to solve the task. Acetylcholine release in the hippocampus, as well as the ratio of acetylcholine release in the hippocampus vs. the dorsal striatum, measured either before or during training, predicted these individual differences in strategy selection during learning. These findings suggest that differences in release of acetylcholine across brain areas may provide a neurobiological marker of individual differences in selection of the strategies rats use to solve a learning task. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:177 / 183
页数:7
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