Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression

被引:148
作者
Benedetti, Francesco
Dallaspezia, Sara
Fulgosi, Mara Cigala
Lorenzi, Cristina
Serretti, Alessandro
Barbini, Barbara
Colombo, Cristina
Smeraldi, Enrico
机构
[1] Univ Milan, Osped San Raffaele, Ist Sci, Dept Neuropsychiat Sci, I-20127 Milan, Italy
[2] Univ Vita Salute San Raffaele, Milan, Italy
关键词
CLOCK gene; polymorphism; bipolar disorder; lithium; insomnia; actigraphy;
D O I
10.1002/ajmg.b.30475
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Depressive insomnia and diurnal fluctuations of mood and activity are core clinical features of mood disorders. Here we studied the effect of CLOCK 3111 T/C SNP (rs1801260) on the actimetric recorded diurnal activity and nocturnal sleep of 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers of the C allele had a similar degree of severity of depression, but showed higher activity levels in the evening, a delayed sleep onset (mean 79 min later), and a reduced amount of sleep during the night (mean 75 min less). Ongoing lithium treatment significantly interacted with rs1801260 by enhancing activity levels in the evening and reducing the differences among genotype groups. Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders. (c) 2007 Wiley-Liss, Inc.
引用
收藏
页码:631 / 635
页数:5
相关论文
共 23 条
[1]   Clock gene expressions in the suprachiasmatic nucleus and other areas of the brain during rhythm splitting in CS mice [J].
Abe, H ;
Honma, S ;
Namihira, M ;
Masubuchi, S ;
Ikeda, M ;
Ebihara, S ;
Honma, K .
MOLECULAR BRAIN RESEARCH, 2001, 87 (01) :92-99
[2]   Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons [J].
Abe, M ;
Herzog, ED ;
Block, GD .
NEUROREPORT, 2000, 11 (14) :3261-3264
[3]   MEASUREMENT OF FEELINGS USING VISUAL ANALOGUE SCALES [J].
AITKEN, RCB .
PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1969, 62 (10) :989-+
[4]   Requirement of circadian genes for cocaine sensitization in Drosophila [J].
Andretic, R ;
Chaney, S ;
Hirsh, J .
SCIENCE, 1999, 285 (5430) :1066-1068
[5]   DEGRADATION OF MESSENGER-RNA IN EUKARYOTES [J].
BEELMAN, CA ;
PARKER, R .
CELL, 1995, 81 (02) :179-183
[6]   Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression [J].
Benedetti, F ;
Serretti, A ;
Colombo, C ;
Barbini, B ;
Lorenzi, C ;
Campori, E ;
Smeraldi, E .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 123B (01) :23-26
[7]   Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-β -50 T/C SNP [J].
Benedetti, F ;
Serretti, A ;
Pontiggia, A ;
Bernasconi, A ;
Lorenzi, C ;
Colombo, C ;
Smeraldi, E .
NEUROSCIENCE LETTERS, 2005, 376 (01) :51-55
[8]   LITHIUM DELAYS CIRCADIAN PHASE OF TEMPERATURE AND REM-SLEEP IN A BIPOLAR DEPRESSIVE - A CASE-REPORT [J].
CAMPBELL, SS ;
GILLIN, JC ;
KRIPKE, DF ;
JANOWSKY, DS ;
RISCH, SC .
PSYCHIATRY RESEARCH, 1989, 27 (01) :23-29
[9]   Lithium- and valproate-induced alterations in circadian locomotor behavior in Drosophila [J].
Dokucu, ME ;
Yu, LP ;
Taghert, PH .
NEUROPSYCHOPHARMACOLOGY, 2005, 30 (12) :2216-2224
[10]   A RATING SCALE FOR DEPRESSION [J].
HAMILTON, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62