Cultured rat sensory neurones express functional tachykinin receptor subtypes 1, 2 and 3

被引：24

作者：

Brechenmacher, C

Larmet, Y

Feltz, P

Rodeau, JL

机构：

[1] CNRS, UPR 9009, Lab Neurobiol Cellulaire, F-67084 Strasbourg, France

[2] Univ Strasbourg 1, URA 1446, Lab Physiol Gen, F-67084 Strasbourg, France

来源：

NEUROSCIENCE LETTERS | 1998年 / 241卷 / 2-3期

关键词：

substance P; tachykinin receptors; sensory neurones; calcium; fura-2; capsaicin;

D O I：

10.1016/S0304-3940(98)00045-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptide substance P (SP) is known to play a key role in peripheral nociceptive processes. We investigated the in vitro pharmacological characteristics of functional tachykinin receptors expressed in dorsal root ganglia (DRG) sensory neurones by analysing intracellular free calcium concentration changes induced after stimulation by SP or specific tachykinin agonists. We observed that about 37% of the tested neurones were responsive to either SP or an NK1-, NK2- or NK3-specific agonist. Tachykinin-responsive neurones had a small soma diameter (<20 mu m) and were sensitive to capsaicin. These results suggest the presence of NK1, NK2 and NK3 receptors in noxious sensory neurones. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：159 / 162

页数：4

共 21 条

[11] PRIMARY SENSORY NEURONS - NEUROFILAMENT, NEUROPEPTIDES, AND CONDUCTION-VELOCITY
LAWSON, SN
PERRY, MJ
PRABHAKAR, E
MCCARTHY, PW
[J]. BRAIN RESEARCH BULLETIN, 1993, 30 (3-4) : 239 - 243
[12] CELL TYPE AND CONDUCTION-VELOCITY OF RAT PRIMARY SENSORY NEURONS WITH SUBSTANCE P-LIKE IMMUNOREACTIVITY
MCCARTHY, PW
LAWSON, SN
[J]. NEUROSCIENCE, 1989, 28 (03) : 745 - 753
[13] NAKANISHI S, 1991, ANNU REV NEUROSCI, V14, P123, DOI 10.1146/annurev.neuro.14.1.123
[14] SUBSTANCE-P - THE 1ST PEPTIDE NEUROTRANSMITTER
OTSUKA, M
KONISHI, S
[J]. TRENDS IN NEUROSCIENCES, 1983, 6 (08) : 317 - 320
[15] OURYDONAT F, 1994, J NEUROCHEM, V62, P1399
[16] DUAL EFFECTS OF SUBSTANCE-P ON THE EXCITABILITY OF SINGLE CUTANEOUS PRIMARY AFFERENT C-FIBERS AND A-FIBERS IN THE CAT SPINAL-CORD
RANDIC, M
CARSTENS, E
ZIMMERMANN, M
KLUMPP, D
[J]. BRAIN RESEARCH, 1982, 233 (02) : 389 - 393
[17] TACHYKININS POTENTIATE N-METHYL-D-ASPARTATE RESPONSES IN ACUTELY ISOLATED NEURONS FROM THE DORSAL HORN
RUSIN, KI
BLEAKMAN, D
CHARD, PS
RANDIC, M
MILLER, RJ
[J]. JOURNAL OF NEUROCHEMISTRY, 1993, 60 (03) : 952 - 960
[18] MODULATION OF EXCITATORY AMINO-ACID RESPONSES IN RAT DORSAL HORN NEURONS BY TACHYKININS
RUSIN, KI
RYU, PD
RANDIC, M
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1992, 68 (01) : 265 - 286
[19] MEASUREMENT OF NEURONAL CA-2+ TRANSIENTS USING SIMULTANEOUS MICROFLUORIMETRY AND ELECTROPHYSIOLOGY
THAYER, SA
STUREK, M
MILLER, RJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1988, 412 (1-2): : 216 - 223
[20] CONTRIBUTION OF NK(1) AND NK(2) RECEPTOR ACTIVATION TO HIGH-THRESHOLD AFFERENT FIBER EVOKED VENTRAL ROOT RESPONSES IN THE RAT SPINAL-CORD IN-VITRO
THOMPSON, SWN
URBAN, L
DRAY, A
[J]. BRAIN RESEARCH, 1993, 625 (01) : 100 - 108

← 1 2 3 →