Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan

被引：46

作者：

Chan, Yu-Jiun ^{[1
,2
,6
]}

Lee, Chia-Ling ^{[6
]}

Hwang, Shinn-Jang ^{[4
]}

Fung, Chang-Phone ^{[1
]}

Wang, Fu-Der ^{[1
]}

Yen, David H. T. ^{[5
,7
]}

Tsai, Cheng-Hsien ^{[2
]}

Chen, Yi-Ming Arthur ^{[8
]}

Lee, Shou-Dong ^{[3
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Med, Div Infect Dis, Taipei 112, Taiwan

[2] Taipei Vet Gen Hosp, Div Clin Virol, Dept Pathol & Lab Med, Taipei 112, Taiwan

[3] Taipei Vet Gen Hosp, Dept Med, Div Gastroenterol, Taipei 112, Taiwan

[4] Taipei Vet Gen Hosp, Dept Family Med, Taipei 112, Taiwan

[5] Taipei Vet Gen Hosp, Dept Emergency Med, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Sch Med, Inst Publ Hlth, Taipei 112, Taiwan

[7] Natl Yang Ming Univ, Sch Med, Inst Emergency & Crit Care Med, Taipei 112, Taiwan

[8] Natl Yang Ming Univ, AIDS Prevent & Res Ctr, Taipei 112, Taiwan

来源：

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION | 2010年 / 73卷 / 02期

关键词：

hemagglutination-inhibition test; hospital staff; H1N1 influenza virus; vaccination; UNITED-STATES; INFECTION; VACCINE; HUMANS;

D O I：

10.1016/S1726-4901(10)70003-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline seroprevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods: A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titers >= 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results: The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 +/- 10.6 years and 52.0 +/- 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group (p=0.925). Conclusion: The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first. [J Chin Med Assoc 2010;73(2):62-66]

引用

页码：62 / 66

页数：5

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