NGF mRNA is expressed in the dorsal root ganglia after spinal cord injury in the rat

被引：63

作者：

Brown, Arthur

Ricci, Mary-Jo

Weaver, Lynne C.

机构：

[1] Robarts Res Inst, Spinal Cord Injury Team, Biotherapeut Res Grp, London, ON, Canada

[2] Robarts Res Inst, Stem Cell & Regenerat Med Program, London, ON N6A 5C1, Canada

[3] Univ Western Ontario, Dept Physiol, London, ON, Canada

[4] Univ Western Ontario, Program Neurosci, London, ON, Canada

来源：

EXPERIMENTAL NEUROLOGY | 2007年 / 205卷 / 01期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.expneurol.2007.01.025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Nerve growth factor (NGF) mRNA is expressed in a variety of cell types in the injured spinal cord and its protein implicated in both positive and negative neurological outcomes of cord injury. Here we demonstrate that NGF mRNA is also upregulated in dorsal root ganglion (DRG) neurons after spinal cord injury and that the percentage of sensory neurons expressing NGF mRNA correlates with proximity to the lesion epicenter. Our data suggest that, in DRG, NGF gene expression may be upregulated by damage to the central processes of sensory neurons. (c) 2007 Elsevier Inc. All rights reserved.

引用

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页码：283 / 286

页数：4

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