Biosynthesis and action of nitric oxide in mammalian cells

被引：506

作者：

Mayer, B ^{[1
]}

Hemmens, B ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Inst Pharmakol & Toxikol, A-8010 Graz, Austria

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 12期

关键词：

D O I：

10.1016/S0968-0004(97)01147-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) can act as a vasorelaxant, a modulator of neurotransmission and a defence against pathogens. However, under certain conditions, NO can also have damaging effects to cells. Whether NO is useful or harmful depends on its chemical fate, and on the rate and location of its production. Here, we discuss progress in NO chemistry and the enzymology of NO synthases, and we will also attempt to explain its actions in the cardiovascular, nervous and immune systems.

引用

页码：477 / 481

页数：5

共 55 条

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