Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity

被引：59

作者：

Autore, Giuseppina ^{[1
]}

Caruso, Anna ^{[1
]}

Marzocco, Stefania ^{[1
]}

Nicolaus, Barbara ^{[2
]}

Palladino, Chiara ^{[1
]}

Pinto, Aldo ^{[1
]}

Popolo, Ada ^{[1
]}

Sinicropi, Maria S. ^{[3
]}

Tommonaro, Giuseppina ^{[2
]}

Saturnino, Carmela ^{[1
]}

机构：

[1] Univ Salerno, Dept Pharmaceut Sci, Fisciano, SA, Italy

[2] CNR, Inst Biomol Chem, Pozzuoli, NA, Italy

[3] Univ Cosenza, Dept Pharmaceut Sci, Arcavacate Di Rende, CS, Italy

来源：

MOLECULES | 2010年 / 15卷 / 03期

关键词：

amides; antioxidant; antiproliferative activity; brine shrimp test; ASSAY;

D O I：

10.3390/molecules15032028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds' structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.

引用

页码：2028 / 2038

页数：11

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