Distribution and function of prostanoid receptors: studies from knockout mice

被引：152

作者：

Sugimoto, Y ^{[1
]}

Narumiya, S

Ichikawa, A

机构：

[1] Kyoto Univ, Fac Pharmaceut Sci, Dept Physiol Chem, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Fac Med, Dept Pharmacol, Sakyo Ku, Kyoto 6068501, Japan

来源：

PROGRESS IN LIPID RESEARCH | 2000年 / 39卷 / 04期

关键词：

prostaglandin; receptor subtypes; cellular localization; aspirin-like drugs; gene targeting;

D O I：

10.1016/S0163-7827(00)00008-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in the molecular biology of the prostanoid receptors has allowed the investigation of the physiological roles of each individual receptor type and subtype. The following article reports the prostanoid receptor distributions deduced from Northern blot and in situ hybridization analyses, summarizes the phenotypes of each receptor knockout mice, and discusses recent studies investigating the effects of each receptor deficiency on the inflammatory response and female reproductive processes. The combination of expression pattern and knockout analyses enabled us to determine which receptor expressed in a particular cell is important for the maintenance of normal and/or pathological physiology. The results from these analyses may be useful in the development of novel therapeutics that can selectively manipulate prostanoid-mediated actions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：289 / 314

页数：26

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