The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor

被引:47
作者
McCarthy, MJ
Crowther, M
Bell, PRF
Brindle, NPJ
机构
[1] Univ Leicester, Dept Surg, Leicester LE2 7LX, Leics, England
[2] Univ Leicester, Inst Cardiovasc Res, RKCSB, Leicester LE2 7LX, Leics, England
来源
FEBS LETTERS | 1998年 / 423卷 / 03期
基金
英国惠康基金;
关键词
angiogenesis; growth factor; hypoxia; receptor;
D O I
10.1016/S0014-5793(98)00122-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The receptor tyrosine kinase tie-1 is essential for angiogenesis where it appears to have a role in vessel maturation, Here we have examined the effects of hypoxia and vascular endothelial growth factor (VEGF) on the level of tie-1 protein expressed in bovine aortic endothelial cells, Both hypoxia (2% O-2) and VEGF were found to increase tie-1 in a time-dependent manner, Hypoxic induction was direct and effects of hypoxia and VEGF were not additive. Experiments with actinomycin D indicate that these activators regulate tie-1 at the transcriptional level. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码:334 / 338
页数:5
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