Should We Measure C-reactive Protein on Earth or Just on JUPITER?

被引：17

作者：

Bajpai, Ambareesh ^{[1
]}

Goyal, Abhinav ^{[1
]}

Sperling, Laurence ^{[1
]}

机构：

[1] Emory Univ, Dept Cardiol, Atlanta, GA 30322 USA

来源：

CLINICAL CARDIOLOGY | 2010年 / 33卷 / 04期

关键词：

CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK PREDICTION; MIDDLE-AGED MEN; FIBRIN D-DIMER; INFLAMMATORY MARKERS; RANDOMIZED-TRIAL; STATIN THERAPY; WOMEN; MORTALITY; INTERLEUKIN-6;

D O I：

10.1002/clc.20681

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence for the role of inflammation in the pathogenesis of atherosclerosis is compelling and has generated interest in high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk. Data regarding hs-CRP and cardiovascular risk, though largely consistent, is of unclear clinical relevance. Most recently, the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial has led to further debate regarding the utility of hs-CRP. This article provides a comprehensive review of the data regarding cardiovascular risk and hs-CRP with an emphasis on the JUPITER trial and concludes with an evidence-based analysis of the current role of hs-CRP in cardiovascular risk assessment.

引用

收藏

页码：190 / 198

页数：9

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