Chlamydia trachomatis - the agent

被引:7
作者
Cevenini, R [1 ]
Donati, M [1 ]
Sambri, V [1 ]
机构
[1] Univ Bologna, Policlin S Orsola, Sez Microbiol, DMCSS, I-40138 Bologna, Italy
关键词
chlamydia trachomatis; elementary body; reticulate body; developmental cycle; major outer membrane protein; lipopolysaccharicle; heat shock protein; glucosaminoglycan-binding chlamydial proteins; inclusion; inclusion membrane proteins; type III protein secretion; polymorphic membrane proteins; pgp3; protein; plasmid;
D O I
10.1053/beog.2002.0323
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Chlamydiae are obligate intracellular bacteria, parasitizing eukaryotic cells. Chlamydia trachomatis, C. psittaci and C. pneumoniae are the three species of chlamydiae pathogenic to humans. C. trachomatis shows a tropism for the genital and conjunctival epithelia and consists of 19 different serovars which are pathogenic predominantly for the urogenital tract. A distinguishing feature of chlamydiae is their transition between the infectious elementary body that enters the host cell and the non-infectious reticulate body that replicates intracellularly within an inclusion that does not fuse with lysosomes. Chlamydiae depend for some functions upon the host cell; in particular, chlamydiae have little capacity for generating energy. The complete sequence of the 1000-kb chromosome of C. trachomatis is known, as are most of the genes located on the 7.5-kb cryptic plasmid. Recently, several concepts about the biology and the metabolic pathways of C. trachomatis have been revised in relation to the genome sequence, and different novel proteins have been described.
引用
收藏
页码:761 / 773
页数:13
相关论文
共 75 条
[11]   EXPRESSION OF A PLASMID GENE OF CHLAMYDIA-TRACHOMATIS ENCODING A NOVEL 28-KDA ANTIGEN [J].
COMANDUCCI, M ;
CEVENINI, R ;
MORONI, A ;
GIULIANI, MM ;
RICCI, S ;
SCARLATO, V ;
RATTI, G .
JOURNAL OF GENERAL MICROBIOLOGY, 1993, 139 :1083-1092
[12]   DIVERSITY OF THE CHLAMYDIA-TRACHOMATIS COMMON PLASMID IN BIOVARS WITH DIFFERENT PATHOGENICITY [J].
COMANDUCCI, M ;
RICCI, S ;
CEVENINI, R ;
RATTI, G .
PLASMID, 1990, 23 (02) :149-154
[13]   Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms [J].
Everett, KDE ;
Bush, RM ;
Andersen, AA .
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1999, 49 :415-440
[14]   CONVERGENT AND OVERLAPPING TRANSCRIPTS OF THE CHLAMYDIA-TRACHOMATIS 7.5-KB PLASMID [J].
FAHR, MJ ;
SRIPRAKASH, KS ;
HATCH, TP .
PLASMID, 1992, 28 (03) :247-257
[15]   Characterization of a new isolate of Chlamydia trachomatis which lacks the common plasmid and has properties of biovar trachoma [J].
Farencena, A ;
Comanducci, M ;
Donati, M ;
Ratti, G ;
Cevenini, R .
INFECTION AND IMMUNITY, 1997, 65 (07) :2965-2969
[16]   Infection with Chlamydia trachomatis alters the tyrosine phosphorylation and/or localization of several host cell proteins including cortactin [J].
Fawaz, FS ;
vanOoij, C ;
Homola, E ;
Mutka, SC ;
Engel, JN .
INFECTION AND IMMUNITY, 1997, 65 (12) :5301-5308
[17]   MURAMIC ACID IS NOT DETECTABLE IN CHLAMYDIA-PSITTACI OR CHLAMYDIA-TRACHOMATIS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].
FOX, A ;
ROGERS, JC ;
GILBART, J ;
MORGAN, S ;
DAVIS, CH ;
KNIGHT, S ;
WYRICK, PB .
INFECTION AND IMMUNITY, 1990, 58 (03) :835-837
[19]   TYPING CHLAMYDIA-TRACHOMATIS BY DETECTION OF RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM IN THE GENE ENCODING THE MAJOR OUTER-MEMBRANE PROTEIN [J].
FROST, EH ;
DESLANDES, S ;
VEILLEUX, S ;
BOURGAUXRAMOISY, D .
JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (05) :1103-1107
[20]   PROPOSAL OF CHLAMYDIA-PECORUM SP-NOV FOR CHLAMYDIA STRAINS DERIVED FROM RUMINANTS [J].
FUKUSHI, H ;
HIRAI, K .
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1992, 42 (02) :306-308