Susceptibility to leprosy is linked to the human NRAMP1 gene

被引：210

作者：

Abel, L

Sánchez, FO

Oberti, J

Thuc, NV

Van Hoa, L

Lap, VD

Skamene, E

Lagrange, PH

Schurr, E

机构：

[1] Montreal Gen Hosp, Res Inst, McGill Ctr Study Host Resistance, Montreal, PQ H3G 1A4, Canada

[2] Hop La Pitie Salpetriere, INSERM, U436, Paris, France

[3] Hop St Louis, Dept Microbiol, Paris, France

[4] Inst Agron Med Montpellier, INSERM, U431, Montpellier, France

[5] McGill Univ, Dept Expt Med, Montreal, PQ H3A 2T5, Canada

[6] McGill Univ, Dept Biochem, Montreal, PQ H3A 2T5, Canada

[7] Dermatol Hosp, Ho Chi Minh City, Vietnam

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 177卷 / 01期

关键词：

D O I：

10.1086/513830

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leprosy is a debilitating infectious disease of human skin and nerves, Genetic factors of the host play an important role in the manifestation of disease susceptibility, The human NRAMP1 gene is a leprosy susceptibility candidate locus since its murine homologue Nramp1 (formerly Lsh/Ity/Bcg) controls innate resistance to Mycobacterium lepraemurium. In this study, 168 members of 20 multiplex leprosy families were genotyped for NRAMP1 alleles and 4 closely linked polymorphic markers, Highly informative haplotypes overlapping the NRAMP1 gene were constructed, and the haplotype segregation into leprosy-affected offspring was analyzed. It was observed that the segregation of NRAMP1 haplotypes into affected siblings was significantly nonrandom, This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus.

引用

页码：133 / 145

页数：13

共 32 条

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