Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres

被引：55

作者：

Coowar, D

Bouissac, J

Hanbali, M

Paschaki, M

Mohier, E

Luu, B

机构：

[1] Univ Strasbourg, CNRS, UMR 7123, Lab Chim Organ Substances Nat, F-67084 Strasbourg, France

[2] Univ Strasbourg, CNRS, UPR 2356, Neurotransmiss & Secret Neuroendocrine, F-67084 Strasbourg, France

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 25期

关键词：

D O I：

10.1021/jm0493616

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

引用

收藏

页码：6270 / 6282

页数：13

相关论文

共 30 条

[1] Stem cells and pattern formation in the nervous system: The possible versus the actual [J].

Anderson, DJ .

NEURON, 2001, 30 (01) :19-35

[2] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[3] The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons [J].

Avramut, M ;

Zeevi, A ;

Achim, CL .

DEVELOPMENTAL BRAIN RESEARCH, 2001, 132 (02) :151-157

[4] The role of neuronal growth factors in neurodegenerative disorders of the human brain [J].

Connor, B ;

Dragunow, M .

BRAIN RESEARCH REVIEWS, 1998, 27 (01) :1-39

[5] Neurotrophic activity of 2,4,4-trimethyl-3-(15-hydroxypentadecyl)-2-cyclohexen-1-one in cultured central nervous system neurons [J].

de Aguilar, JLG ;

Girlanda-Junges, C ;

Coowar, D ;

Duportail, G ;

Loeffler, JP ;

Luu, B .

BRAIN RESEARCH, 2001, 920 (1-2) :65-73

[6]

Ding S, 2003, P NATL ACAD SCI USA, V100, P7632, DOI 10.1073/pnas.0732087100

[7] A role for chemistry in stem cell biology [J].

Ding, S ;

Schultz, PG .

NATURE BIOTECHNOLOGY, 2004, 22 (07) :833-840

[8] VILSMEIER FORMYLATION AND GLYOXYLATION REACTIONS OF NUCLEOPHILIC AROMATIC-COMPOUNDS USING PYROPHOSPHORYL CHLORIDE [J].

DOWNIE, IM ;

EARLE, MJ ;

HEANEY, H ;

SHUHAIBAR, KF .

TETRAHEDRON, 1993, 49 (19) :4015-4034

[9] Mammalian neural stem cells [J].

Gage, FH .

SCIENCE, 2000, 287 (5457) :1433-1438

[10] Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship [J].

Girlanda-Junges, C ;

Keyling-Bilger, F ;

Schmitt, G ;

Luu, B .

TETRAHEDRON, 1998, 54 (27) :7735-7748