Simulation and visualization of flow pattern in microarrays for liquid phase oligonucleotide and peptide synthesis

被引：7

作者：

O-Charoen, Sirimon ^{[1
]}

Srivannavit, Onnop ^{[1
]}

Gulari, Erdogan ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA

来源：

BIOTECHNOLOGY PROGRESS | 2007年 / 23卷 / 03期

关键词：

D O I：

10.1021/bp060363o

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microfluidic microarrays have been developed for economical and rapid parallel synthesis of oligonucleotide and peptide libraries. For a synthesis system to be reproducible and uniform, it is crucial to have a uniform reagent delivery throughout the system. Computational fluid dynamics ( CFD) is used to model and simulate the microfluidic microarrays to study geometrical effects on flow patterns. By proper design geometry, flow uniformity could be obtained in every microreactor in the microarrays.

引用

页码：755 / 761

页数：7

共 24 条

[21]

SRIVANNAVIT O, 2002, THESIS U MICHIGAN

[22] Fluid modelling of microfluidic separator channels [J].

Townsend, RJ ;

Hill, M ;

Harris, NR ;

White, NM ;

Beeby, SP ;

Wood, RJK .

SENSORS AND ACTUATORS B-CHEMICAL, 2005, 111 :455-462

[23] Numerical investigation of mixing in microchannels with patterned grooves [J].

Wang, HZ ;

Iovenitti, P ;

Harvey, E ;

Masood, S .

JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2003, 13 (06) :801-808

[24] Lab-on-a-chip sample preparation using laminar fluid diffusion interfaces - computational fluid dynamics model results and fluidic verification experiments [J].

Weigl, BH ;

Bardell, RL ;

Kesler, N ;

Morris, CJ .

FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 2001, 371 (02) :97-105

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