Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus

被引：114

作者：

Holst, JJ ^{[1
]}

Deacon, CF ^{[1
]}

机构：

[1] Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen N, Denmark

来源：

CURRENT OPINION IN PHARMACOLOGY | 2004年 / 4卷 / 06期

关键词：

D O I：

10.1016/j.coph.2004.08.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Proof-of-concept for the efficacy of a glucagon-like peptide 1 (GLP-1)-based therapy of patients with type 2 diabetes was provided in 2002 by means of prolonged continuous subcutaneous infusion of native GLP-1. Since then, several long-acting analogues of GLP-1, as well as inhibitors of dipeptidyl peptidase IV, the enzyme that rapidly inactivates endogenous GLP-1, have demonstrated efficacy in long term clinical trials.

引用

页码：589 / 596

页数：8

共 70 条

[1] Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
Ahrén, B
Landin-Olsson, M
Jansson, PA
Svensson, M
Holmes, D
Schweizer, A
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (05) : 2078 - 2084
[2] Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
Ahrén, B
Simonsson, E
Larsson, H
Landin-Olsson, M
Torgeirsson, H
Jansson, PA
Sandqvist, M
Båvenholm, P
Efendic, S
Eriksson, JW
Dickinson, S
Holmes, D
[J]. DIABETES CARE, 2002, 25 (05) : 869 - 875
[3] AHREN B, 64 SCI SESS AM DIAB
[4] Bloom M, 2003, DIABETES, V52, pA112
[5] BOSE KA, 2004, IN PRESS DIABETES
[6] Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
Bullock, BP
Heller, RS
Habener, JF
[J]. ENDOCRINOLOGY, 1996, 137 (07) : 2968 - 2978
[7] Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
Buteau, J
Roduit, R
Susini, S
Prentki, M
[J]. DIABETOLOGIA, 1999, 42 (07) : 856 - 864
[8] Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
Buteau, J
El-Assaad, W
Rhodes, CJ
Rosenberg, L
Joly, E
Prentki, M
[J]. DIABETOLOGIA, 2004, 47 (05) : 806 - 815
[9] Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
Conarello, SL
Li, ZH
Ronan, J
Roy, RS
Zhu, L
Jiang, GQ
Liu, F
Woods, J
Zycband, E
Moller, DE
Thornberry, NA
Zhang, BB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (11) : 6825 - 6830
[10] Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig
Deacon, CF
Hughes, TE
Holst, JJ
[J]. DIABETES, 1998, 47 (05) : 764 - 769

← 1 2 3 4 5 6 7 →