Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus

被引：114

作者：

Holst, JJ ^{[1
]}

Deacon, CF ^{[1
]}

机构：

[1] Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen N, Denmark

来源：

CURRENT OPINION IN PHARMACOLOGY | 2004年 / 4卷 / 06期

关键词：

D O I：

10.1016/j.coph.2004.08.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Proof-of-concept for the efficacy of a glucagon-like peptide 1 (GLP-1)-based therapy of patients with type 2 diabetes was provided in 2002 by means of prolonged continuous subcutaneous infusion of native GLP-1. Since then, several long-acting analogues of GLP-1, as well as inhibitors of dipeptidyl peptidase IV, the enzyme that rapidly inactivates endogenous GLP-1, have demonstrated efficacy in long term clinical trials.

引用

页码：589 / 596

页数：8

共 70 条

[61]

Weber AE, 2004, DIABETES, V53, pA151

[62] TRUNCATED GLP-1 (PROGLUCAGON 78-107-AMIDE) INHIBITS GASTRIC AND PANCREATIC FUNCTIONS IN MAN [J].

WETTERGREN, A ;

SCHJOLDAGER, B ;

MORTENSEN, PE ;

MYHRE, J ;

CHRISTIANSEN, J ;

HOLST, JJ .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (04) :665-673

[63] Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats [J].

Xu, G ;

Stoffers, DA ;

Habener, JF ;

Bonner-Weir, S .

DIABETES, 1999, 48 (12) :2270-2276

[64]

Yamamoto H, 2003, J NEUROSCI, V23, P2939

[65] Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons [J].

Yamamoto, H ;

Lee, CE ;

Marcus, JN ;

Williams, TD ;

Overton, JM ;

Lopez, ME ;

Hollenberg, AN ;

Baggio, L ;

Saper, CB ;

Drucker, DJ ;

Elmquist, JK .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (01) :43-52

[66] Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer rats [J].

Yasuda, N ;

Nagakura, T ;

Yamazaki, K ;

Inoue, T ;

Tanaka, I .

LIFE SCIENCES, 2002, 71 (02) :227-238

[67]

Young A, 1998, NUTRITION, V14, P524

[68] Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes:: a parallel-group study [J].

Zander, M ;

Madsbad, S ;

Madsen, JL ;

Holst, JJ .

LANCET, 2002, 359 (9309) :824-830

[69] Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells [J].

Zhou, J ;

Wang, XL ;

Pineyro, MA ;

Egan, JM .

DIABETES, 1999, 48 (12) :2358-2366

[70] The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides -: In vivo metabolism of pituitary adenylate cyclase-activating polypeptide-(1-38) [J].

Zhu, L ;

Tamvakopoulos, C ;

Xie, D ;

Dragovic, J ;

Shen, XL ;

Fenyk-Melody, JE ;

Schmidt, K ;

Bagchi, A ;

Griffin, PR ;

Thornberry, NA ;

Roy, RS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (25) :22418-22423

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