Solid-phase synthesis of styryl dyes and their application as amyloid sensors

被引：128

作者：

Li, QA

Lee, JS

Ha, C

Park, CB

Yang, G

Gan, WB

Chang, YT ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

[2] Arizona State Univ, Dept Chem & Mat Engn, Tempe, AZ 85287 USA

[3] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 46期

关键词：

combinatorial chemistry; dyes/pigments; fluorescent probes; imaging agents; solid-phase synthesis;

D O I：

10.1002/anie.200461600

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents (see microscopy image). (Chemical equation presented).

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收藏

页码：6331 / 6335

页数：5

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