The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress

被引：30

作者：

Kunstmann, Birgit

Osiewacz, Heinz D. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Biol Sci, D-60438 Frankfurt, Germany

来源：

AGING-US | 2009年 / 1卷 / 03期

关键词：

Podospora anserina; knock-out; reactive oxygen species; flavonoids; ageing; O-methyltransferase; LIFE-SPAN CONTROL; COPPER; DAMAGE; SENESCENCE; EXPRESSION; BRAIN; GENE; AGE; IDENTIFICATION; ACCUMULATION;

D O I：

10.18632/aging.100029

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about the function of the protein in the protection against metal induced oxidative stress. Deletion of PaMth1 was found to lead to a decreased-resistance against exogenous oxidative stress and to a shortened lifespan suggesting a role of PaMTH1 as a longevity assurance factor in a new molecular pathway involved in lifespan control.

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收藏

页码：328 / 334

页数：7

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