Child's stress hormone levels correlate with mother's socioeconomic status and depressive state

被引:356
作者
Lupien, SJ
King, S
Meaney, MJ
McEwen, BS
机构
[1] McGill Univ, Douglas Hosp, Dept Res, Res Ctr, Montreal, PQ H4H 1R3, Canada
[2] Montreal Geriatr Inst, Res Ctr, Montreal, PQ, Canada
[3] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA
关键词
children; socioeconomic status; cortisol; depression;
D O I
10.1016/S0006-3223(00)00965-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Individuals with lower socioeconomic status report greater exposure ro stressful life events and a greater impact of these events on their lives than individuals with higher socioeconomic status, and this relationship between socioeconomic status and health begins at the earliest stages of life. To extend on these results, we performed a psychoneuroendocrine study of 217 children and 139 mothers. Methods: Salivary cortisol levels and cognitive function were assessed in children, and a semistructured phone interview measuring symptoms of stress and depression was conducted with their mothers. Results: Children with low socioeconomic status present significantly,higher salivary cortisol levels than children with high socioeconomic status, and this socioeconomic status effect emerges as early as age 6, We also report that a child's cortisol level is significantly correlated with his or her mother's extent of depressive symptomatology. Conclusions: These results offer a neurobiological determinant to the well-known association between socioeconomic status and health that begins early in life. (C) 2000 Society of Biological Psychiatry.
引用
收藏
页码:976 / 980
页数:5
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