Strategy and methodology development for the total synthesis of polyether ionophore antibiotics

被引：381

作者：

Faul, MM ^{[1
]}

Huff, BE ^{[1
]}

机构：

[1] Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

CHEMICAL REVIEWS | 2000年 / 100卷 / 06期

关键词：

D O I：

10.1021/cr940210s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total syntheses of all polyether ionophores prepared to date are presented in order of the year that the synthesis was published. For each synthesis, the retrosynthetic approach is introduced. Discussion of the fragment synthesis is limited to those reactions that establish stereochemistry by acyclic stereocontrol.

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页码：2407 / 2473

页数：67

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