Percolation, morphogenesis, and Burgers dynamics in blood vessels formation

被引:194
作者
Gamba, A [1 ]
Ambrosi, D
Coniglio, A
de Candia, A
Di Talia, S
Giraudo, E
Serini, G
Preziosi, L
Bussolino, F
机构
[1] Politecn Torino, Dipartimento Matemat, I-10129 Turin, Italy
[2] Univ Naples Federico 2, Dipartimento Sci Fisiche, I-80126 Naples, Italy
[3] INFM, Unita Napoli, I-80126 Naples, Italy
[4] Ist Ric Cura Canc, I-10060 Candiolo, TO, Italy
关键词
D O I
10.1103/PhysRevLett.90.118101
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.
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页数:4
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