Selection and amplification of a catalyst from a dynamic combinatorial library

被引：131

作者：

Brisig, B

Sanders, JKM

Otto, S

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Basel, Dept Inorgan Chem, CH-4056 Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 11期

关键词：

catalysis; combinatorial chemistry; host-guest chemistry; supramolecular chemistry; thermodynamic control;

D O I：

10.1002/anie.200390326

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amplification of the fittest: A dynamic combinatorial library (DCL) of macrocyclic disulfides in water was exposed to a transition-state analogue (TSA) for a Diels-Alder reaction. Two receptors were selected and amplified, of which one binds to the TSA more strongly than to the starting material and catalyzes the Diels-Alder reaction (see scheme).

引用

收藏

页码：1270 / 1273

页数：4

相关论文

共 33 条

[1] DIRECTED EVOLUTION OF AN RNA ENZYME [J].

BEAUDRY, AA ;

JOYCE, GF .

SCIENCE, 1992, 257 (5070) :635-641

[2]

Berl V, 1999, EUR J ORG CHEM, V1999, P3089

[3] Selection approaches to catalytic systems [J].

Brady, PA ;

Sanders, JKM .

CHEMICAL SOCIETY REVIEWS, 1997, 26 (05) :327-336

[4]

FROST AA, 1980, KINETICS MECH

[5] Molecular amplification in a dynamic system by ammonium cations [J].

Furlan, RLE ;

Ng, YF ;

Cousins, GRL ;

Redman, JE ;

Sanders, JKM .

TETRAHEDRON, 2002, 58 (04) :771-778

[6] A new cyclic pseudopeptide receptor for Li+ from a dynamic combinatorial library [J].

Furlan, RLE ;

Ng, YF ;

Otto, S ;

Sanders, JKM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (36) :8876-8877

[7] Molecular amplification in a dynamic combinatorial library using non-covalent interactions [J].

Furlan, RLE ;

Cousins, GRL ;

Sanders, JKM .

CHEMICAL COMMUNICATIONS, 2000, (18) :1761-1762

[8] Chemical evolution: A model system that selects and amplifies a receptor for the tripeptide (D)Pro(L)Val(D)Val [J].

Hioki, H ;

Still, WC .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (04) :904-905

[9] Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries [J].

Hochgürtel, M ;

Kroth, H ;

Piecha, D ;

Hofmann, MW ;

Nicolau, C ;

Krause, S ;

Schaaf, O ;

Sonnenmoser, G ;

Eliseev, AV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3382-3387

[10] Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly [J].

Huc, I ;

Lehn, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2106-2110

← 1 2 3 4 →