Bioactive carotenoids: potent antioxidants and regulators of gene expression

被引:50
作者
Hix, LM
Lockwood, SF
Bertram, JS
机构
[1] Univ Hawaii Manoa, Canc Res Ctr Hawaii, Honolulu, HI 96813 USA
[2] Univ Hawaii Manoa, Dept Cell & Mol Biol, Honolulu, HI 96813 USA
[3] Hawaii Biotech Inc, Aiea, HI USA
关键词
carotenoids; vitamin A; anti-neoplastic properties; astaxanthin derivative;
D O I
10.1179/135100004225005967
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Carotenoids are plant pigments, some of which act as a vital source of vitamin A to all animals, that appear to have additional benefits to primates. They are potent antioxidants and photoprotectants and can additionally modulate gene activity resulting in protection from experimentally-induced inflammatory damage and neoplastic transformation. Anti-neoplastic properties appear tightly correlated to their ability to induce the gap junctional protein connexin 43 (Cx43). This when up-regulated leads to decreased proliferation and decreased indices of neoplasia in animal and human cells. Delivery of natural carotenoids can be compromised by poor bioavailability. To overcome this, a synthetic water-dispersible derivative of astaxanthin has been synthesized and shown to be: highly bioavailable; a potent antioxidant; protective against experimental ischemia-reperfusion injury and capable of inducing Cx43, suggesting antineoplastic potential. The ability to deliver biologically active carotenoids at high concentration and with good reproducibility appears to have been achieved.
引用
收藏
页码:181 / 191
页数:11
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