ESTROGEN MODULATES INHIBITORY CONTROL IN HEALTHY HUMAN FEMALES: EVIDENCE FROM THE STOP-SIGNAL PARADIGM

被引:97
作者
Colzato, L. S. [1 ,2 ]
Hertsig, G. [1 ,2 ]
Van Den Wildenberg, W. P. M. [3 ]
Hommel, B. [1 ,2 ]
机构
[1] Leiden Univ, Cognit Psychol Unit, NL-2300 RB Leiden, Netherlands
[2] Leiden Univ, Leiden Inst Brain & Cognit, NL-2300 RB Leiden, Netherlands
[3] Univ Amsterdam, Dept Psychol, Amsterdam Ctr Study Adapt Control Brain & Behav A, NL-1018 WB Amsterdam, Netherlands
关键词
inhibition control; estrogen; stop-signal task; dopamine; gender differences; MENSTRUAL-CYCLE PHASE; RESPONSE-INHIBITION; PARKINSONS-DISEASE; SALIVARY ESTRADIOL; GENDER-DIFFERENCES; WORKING-MEMORY; SMOKED COCAINE; LUTEAL PHASES; D-AMPHETAMINE; DOPAMINE;
D O I
10.1016/j.neuroscience.2010.02.029
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Animal studies point to a role of estrogen in explaining gender differences in striatal dopaminergic functioning, but evidence from human studies is still lacking. Given that dopamine is crucial for controlling and organizing goal-directed behavior, estrogen may have a specific impact on cognitive control functions, such as the inhibition of prepotent responses. We compared the efficiency of inhibitory control (as measured by the stop-signal task) in young women across the three phases of their menstrual cycle (salivary estradiol and progesterone concentrations were assessed) and in young men. Women were less efficient in inhibiting prepotent responses in their follicular phase, which is associated with higher estradiol levels and with higher dopamine turnover rates, than in their luteal or menstruation phase. Likewise, women showed less efficient inhibitory control than men in their follicular phase but not in their luteal or menstruation phase. Our results are consistent with models assuming that the over-supply of striatal dopamine in the follicular phase weakens inhibitory pathways, thus leading to enhanced competition between responses. We conclude that gender differences in response inhibition are variable and state dependent but not structural. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:709 / 715
页数:7
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