Prospects for xenotransplantation

被引：58

作者：

Logan, JS ^{[1
]}

机构：

[1] Nextran Inc, Princeton, NJ 08540 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(00)00139-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pig-to-primate organ survival has been extended from a few minutes to weeks and occasionally months, following the development of transgenic pigs that express human complement-regulatory proteins, efficient antibody removal technologies and immunosuppressive strategies. The current limitation to the clinical application of this technology is acute vascular rejection, and an understanding of the mechanisms of this process and the development of modalities to overcome it are key to making significant progress at solving the critical shortage of organs for transplantation. Approaches that address this issue are underway in a number of laboratories.

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页码：563 / 568

页数：6

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