Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension

被引:112
作者
Tuomilehto, J
Lindström, J
Hyyrynen, J
Korpela, R
Karhunen, ML
Mikkola, L
Jauhiainen, T
Seppo, L
Nissinen, A
机构
[1] Natl Publ Hlth Inst, Diabet & Genet Epidemiol Unit, Dept Epidemiol & Hlth Promot, FIN-00300 Helsinki, Finland
[2] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[3] Valio Ltd R&D, Helsinki, Finland
[4] Univ Helsinki, Inst Biomed, Helsinki, Finland
[5] Univ Kuopio, Dept Community Hlth & Gen Practice, FIN-70211 Kuopio, Finland
关键词
blood pressure; tripeptides; sour milk; ACE inhibition; Lactobacillus helveticus bacteria;
D O I
10.1038/sj.jhh.1001745
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Angiotensin-converting enzyme (ACE) is important in the regulation of blood pressure (BP). Two tripeptides that inhibit ACE, isoleucyl-prolyl-proline (Ile-Pro-Pro) and valyl-prolyl-proline (Val-Pro-Pro), have been isolated from certain sour milks. The aim of the study reported was to evaluate the effect on BP in subjects with mild hypertension of a new sour milk containing tripeptides. The initial number of subjects was 60 (36 men, 24 women). Among the criteria for inclusion in the study were systolic BP (SBP) between 140 and 180 mmHg and/or diastolic BP (DPB) between 90 and 110 mmHg, without antihypertensive drug therapy. There were two study periods with a washout period between. All subjects were given 1.5 dl per day of a placebo (regular sour milk) or of the active product, a milk that had been fermented with Lactobacillus helveticus bacteria and contained 2.4-2.7 mg of Ile-Pro-Pro and 2.4-2.7 mg of Val-Pro-Pro per 1.5 dl. In the first phase, SBP fell 16 mmHg from baseline in the active group, 2 mmHg more than in the placebo group (P=0.0668) and no difference in DBP (P=0.92). There was a statistically significant downward trend both in SBP and DBP (P=0.0001). During the second phase, SBP fell 11 mmHg in the active group (P=0.008). The reduction in SBP was significantly larger in active than placebo group (P=0.012). In the crossover analysis combining both phases, SBP fell on average 2.6+/-15.9 mmHg more on the active product compared with the placebo product, but this difference was not statistically significant (P=0.3111). The difference in DBP, 1.0+/-8.3 mmHg between the two test products was not significant either (P=0.4431). In conclusion, the ingestion of sour milk fermented by L. helveticus bacteria and that containing ACE inhibitory tripeptides seems to lower BP modestly.
引用
收藏
页码:795 / 802
页数:8
相关论文
共 24 条
[1]   ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS DERIVED FROM FOOD PROTEINS [J].
ARIYOSHI, Y .
TRENDS IN FOOD SCIENCE & TECHNOLOGY, 1993, 4 (05) :139-144
[2]   BLOOD-PRESSURE, STROKE, AND CORONARY HEART-DISEASE .2. SHORT-TERM REDUCTIONS IN BLOOD-PRESSURE - OVERVIEW OF RANDOMIZED DRUG TRIALS IN THEIR EPIDEMIOLOGIC CONTEXT [J].
COLLINS, R ;
PETO, R ;
MACMAHON, S ;
HEBERT, P ;
FIEBACH, NH ;
EBERLEIN, KA ;
GODWIN, J ;
QIZILBASH, N ;
TAYLOR, JO ;
HENNEKENS, CH .
LANCET, 1990, 335 (8693) :827-838
[3]   LONG-TERM REPRODUCIBILITY AND EVALUATION OF SEASONAL INFLUENCE ON BLOOD-PRESSURE MONITORING [J].
GIACONI, S ;
PALOMBO, C ;
GENOVESIEBERT, A ;
MARABOTTI, C ;
VOLTERRANI, D ;
GHIONE, S .
JOURNAL OF HYPERTENSION, 1988, 6 :S64-S66
[4]   Placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects [J].
Hata, Y ;
Yamamoto, M ;
Ohni, M ;
Nakajima, K ;
Nakamura, Y ;
Takano, T .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1996, 64 (05) :767-771
[5]   BY HOW MUCH DOES DIETARY SALT REDUCTION LOWER BLOOD-PRESSURE .3. ANALYSIS OF DATA FROM TRIALS OF SALT REDUCTION [J].
LAW, MR ;
FROST, CD ;
WALD, NJ .
BMJ-BRITISH MEDICAL JOURNAL, 1991, 302 (6780) :819-824
[6]   EMERGING ROLE OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS IN CARDIAC AND VASCULAR PROTECTION [J].
LONN, EM ;
YUSUF, S ;
JHA, P ;
MONTAGUE, TJ ;
TEO, KK ;
BENEDICT, CR ;
PITT, B .
CIRCULATION, 1994, 90 (04) :2056-2069
[7]  
MacGregor G A, 1999, Nutr Metab Cardiovasc Dis, V9, P6
[8]   Blood pressure lowering for the secondary prevention of myocardial infarction and stroke [J].
MacMahon, S ;
Rodgers, A ;
Neal, B ;
Chalmers, J .
HYPERTENSION, 1997, 29 (02) :537-538
[9]   ANGIOTENSIN-I-CONVERTING ENZYME-INHIBITOR DERIVED FROM AN ENZYMATIC HYDROLYSATE OF CASEIN .2. ISOLATION AND BRADYKININ-POTENTIATING ACTIVITY ON THE UTERUS AND THE ILEUM OF RATS [J].
MARUYAMA, S ;
NAKAGOMI, K ;
TOMIZUKA, N ;
SUZUKI, H .
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, 49 (05) :1405-1409
[10]   Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats [J].
Masuda, O ;
Nakamura, Y ;
Takano, T .
JOURNAL OF NUTRITION, 1996, 126 (12) :3063-3068