共 51 条
Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease
被引:155
作者:
Choo, Il Han
[1
,2
]
Lee, Dong Young
[1
,2
,3
]
Oh, Jungsu S.
[4
]
Lee, Jae Sung
[4
]
Lee, Dong Soo
[3
,4
]
Song, In Chan
[5
]
Youn, Jong Choul
[6
]
Kim, Shin Gyeom
[1
,2
]
Kim, Ki Woong
[7
]
Jhoo, Jin Hyeong
[8
]
Woo, Jong Inn
[1
,2
,3
,9
]
机构:
[1] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul 110744, South Korea
[2] Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea
[3] Seoul Natl Univ, Interdisciplinary Program Cognit Sci, Seoul, South Korea
[4] Seoul Natl Univ Hosp, Dept Nucl Med, Seoul 110744, South Korea
[5] Seoul Natl Univ Hosp, Dept Radiol, Seoul 110744, South Korea
[6] Kyunggi Prov Hosp Elderly, Dept Neuropsychiat, Yongin, Kyunggi, South Korea
[7] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam, Kyunggi, South Korea
[8] Kangwon Natl Univ Hosp, Dept Psychiat, Chunchon, Kangwon, South Korea
[9] Seoul Natl Univ, Neurosci Res Inst, Med Res Ctr, Seoul, South Korea
关键词:
Posterior cingulate cortex;
Entorhinal cortex;
Hippocampus;
Cingulum;
Medial temporal lobe;
Atrophy;
Volume;
Fractional anisotropy;
WHITE-MATTER;
ENTORHINAL CORTEX;
HIPPOCAMPAL VOLUME;
MRI MEASURES;
DEMENTIA;
PET;
HYPOMETABOLISM;
TRACTOGRAPHY;
REDUCTION;
ATLAS;
D O I:
10.1016/j.neurobiolaging.2008.06.015
中图分类号:
R592 [老年病学];
C [社会科学总论];
学科分类号:
03 ;
0303 ;
100203 ;
摘要:
This study aimed to investigate the atrophy of the posterior cingulate cortex (PCC) and medical temporal lobe (MTL) structures (i.e., the entorhinal cortex (ERC) and hippocampus) and the regional disruption of the cingulum bundle in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. The relationships between atrophy of these structures and regional cingulum disruption were also explored. Three-dimensional MRI and diffusion tensor imaging were applied to 19 MCI, 19 probable AD patients, and 18 normal controls (NC). Fractional anisotropy (FA) values were obtained from three different regions of the cingulum. Both MCI and AD patients showed decreased PCC volumes compared with NC. ERC atrophy was also significant in AD and MCI, while hippocampus atrophy was significant only in AD. MCI patients showed a significant FA decrease in the parahippocampal cingulum (PH-C), whereas AD patients had lower FA values in the posterior cingulate cingulum (PC-C) and PH-C, as compared with NC. However, the middle cingulate cingulum (MC-C) showed no significant FA differences between groups. Moreover, the volumes of MTL structures were significantly correlated with PH-C and PC-C FA values. In terms of PCC functional deficit in MCI or early AD, our results support both the direct effect of PCC atrophy itself and the indirect effect of cingulum fiber degeneration secondary to MTL atrophy. (C) 2008 Elsevier Inc. All rights reserved.
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页码:772 / 779
页数:8
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