Ataxia, arrhythmia and ion-channel gene defects

被引：39

作者：

Doyle, JL ^{[1
]}

Stubbs, L ^{[1
]}

机构：

[1] Oak Ridge Natl Lab, Div Life Sci, Oak Ridge, TN 37831 USA

来源：

TRENDS IN GENETICS | 1998年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0168-9525(97)01370-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ion channels are essential to a wide range of physiological functions including neuronal signaling, muscle contraction cardiac pacemaking, hormone secretion and cell proliferation The important role that highly regulated ion influx plays In these processes has been underscored by a recent flurry of discovered linking ion-channel gene mutations to inherited disorders. Ion channels of many, different types hare been demonstrated as being causative factors. In genetic disease This review discusses the growing number of disorders associated with genes of the voltage-gated ion channel superfamily with special focus on those characterized by neurological, neuromuscular, or cardiac dysfunction in humans and mice.

引用

页码：92 / 98

页数：7

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