γδ+ T cells preferentially respond to live rather than killed malaria parasites

被引：45

作者：

Waterfall, M ^{[1
]}

Black, A ^{[1
]}

Riley, E ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell Anim & Populat Biol, Ashworth Labs, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.66.5.2393-2398.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

have compared the in vitro responses of peripheral blood T cells from malaria-unexposed donors to live Plasmodium falciparum schizonts, freeze-thawed schizont extracts (P. falciparum schizont extracts [PfSE]), and parasite culture supernatants. We show that the cells responding to PfSE and parasite culture supernatants are predominantly CD4(+) TCR alpha beta(+) while in the presence of live schizonts there is an additional activation of TCR gamma delta(+) cells. Activation of TCR gamma delta(+) cells in response to PfSE was seen only when irradiated autologous feeder cells or recombinant interleukin-2 (IL-2) was added to the cultures. Live schizonts but not PfSE induced significant IL-2 production in vitro in the first 5 days after stimulation, suggesting that induction of early IL-2 by live parasites may contribute to the marked activation of the TCR gamma delta(+) population.

引用

页码：2393 / 2398

页数：6

共 39 条

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