Alginate/chitosan nanoparticles for encapsulation and controlled release of vitamin B2

This work aims at evaluating encapsulation and controlled release of vitamin B-2 from alginate/chitosan nanoparticles. Ionotropic polyelectrolyte pre-gelation was used as production method being chitosan and alginate used as main materials. Nanoparticles were characterized in terms of average size, polydispersity index (PDI), zeta potential and vitamin entrapment efficiency. The average size for alginate/chitosan nanoparticles was 119.5 +/- 49.9 nm for samples without vitamin B-2 and 104.0 +/- 67.2 nm with the encapsulation of vitamin B-2, presenting a PDI of 0.454 +/- 0.066 and 0.319 +/- 0.068, respectively. The nanoparticles showed encapsulation efficiency and loading capacity values of 55.9 +/- 5.6% and 2.2 +/- 0.6%, respectively. Release profiles were evaluated at different conditions showing that the polymeric relaxation was the most influent phenomenon in vitamin B-2 release. In order to study their stability nanoparticles were stored at 4 degrees C being particles sizes and PDI evaluated during 5 months showing the results that vitamin B-2-loaded nanoparticles are more stable (in terms of size and PDI) than nanoparticles without vitamin B-2. (C) 2014 Elsevier B.V. All rights reserved.