Temperature and pH responsive polymers based on chitosan: Applications and new graft copolymerization strategies based on living radical polymerization

被引：126

作者：

Carreira, A. S. ^{[1
]}

Goncalves, F. A. M. M. ^{[1
]}

Mendonca, P. V. ^{[1
]}

Gil, M. H. ^{[1
]}

Coelho, J. F. J. ^{[1
]}

机构：

[1] Univ Coimbra, Dept Chem Engn, P-3030290 Coimbra, Portugal

来源：

CARBOHYDRATE POLYMERS | 2010年 / 80卷 / 03期

关键词：

Chitosan; Temperature and pH responsive; Hydrogels; Particulate carriers; DRUG-RELEASE BEHAVIOR; TUMOR EXTRACELLULAR PH; SENSITIVE HYDROGELS; IN-VITRO; N-ISOPROPYLACRYLAMIDE; DEPENDENT HYDROLYSIS; NETWORK MICROSPHERES; STRUCTURAL-CHANGES; INTERPOLYMERIC PH; DELIVERY-SYSTEMS;

D O I：

10.1016/j.carbpol.2009.12.047

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The present review aims to highlight the applications of pH and temperature responsive chitosan-based polymers. Such materials are used in the development of several applications, such as drug delivery systems, bioseparation devices, tissue engineering scaffolds, cell culture supports, sensors or actuators systems. Advances in this field are particularly relevant to applications in the areas of regenerative medicine and drug delivery. This review addresses mainly smart polymers, derived from chitosan, including particulate carrier systems, hydrogels and film based materials that are responsive to stimuli such as temperature and pH. A survey of the major contributions is presented. Finally, this review summarizes and analyses recent developments in the field of graft modification of chitosan by living radical polymerization. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：618 / 630

页数：13

共 87 条

[1]

Chitosan-based interpolymeric pH-responsive hydrogels for in vitro drug release [J].

Abdelaal, M. Y. ;

Abdel-Razik, E. A. ;

Abdel-Bary, E. M. ;

El-Sherbiny, I. M. .

JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 103 (05) :2864-2874

[2]

AGUILAR MR, 2008, SMART POLYM THEIR AP

[3]

Immobilization of drugs for glaucoma treatment [J].

Almeida, Jose Filipe ;

Fonseca, Anabela ;

Baptista, Cristina M. S. G. ;

Leite, Eugenio ;

Gil, Maria Helena .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2007, 18 (12) :2309-2317

[4]

Belgacem MN, 2008, MONOMERS, POLYMERS AND COMPOSITES FROM RENEWABLE RESOURCES, P1

[5]

Controlled/living radical polymerization: Features, developments, and perspectives [J].

Braunecker, Wade A. ;

Matyjaszewski, Krzysztof .

PROGRESS IN POLYMER SCIENCE, 2007, 32 (01) :93-146

[6]

Synthesis and characterization of thermo- and pH-sensitive hydrogels based on Chitosan-grafted N-isopropylacrylamide via γ-radiation [J].

Cai, H ;

Zhang, ZP ;

Sun, PC ;

He, BL ;

Zhu, XX .

RADIATION PHYSICS AND CHEMISTRY, 2005, 74 (01) :26-30

[7]

Preparation and characterization of a novel IPN hydrogel memberane of poly(N-isopropylacrylamide)/carboxymethyl chitosan (PNIPAAM/CMCS) [J].

Chen, Jie ;

Sun, Jie ;

Yang, Liming ;

Zhang, Qunfei ;

Zhu, Huina ;

Wu, Huifeng ;

Hoffman, Allan S. ;

Kaetsu, Isao .

RADIATION PHYSICS AND CHEMISTRY, 2007, 76 (8-9) :1425-1429

[8]

Applications of chitosan-based thermo-sensitive copolymers for harvesting living cell sheet [J].

Chen, Jyh-Ping ;

Yang, Tze-Feng .

APPLIED SURFACE SCIENCE, 2008, 255 (02) :297-300

[9]

Functionalized temperature-sensitive copolymer for tissue engineering of articular cartilage and meniscus [J].

Chen, Jyh-Ping ;

Cheng, Tai-Hong .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2008, 313 :254-259

[10]

Thermo-responsive chitosan-graft-poly(N-isopropylacrylamide) injectable hydrogel for cultivation of chondrocytes and meniscus cells [J].

Chen, Jyh-Ping ;

Cheng, Tai-Hong .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (12) :1026-1039

← 1 2 3 4 5 6 7 8 9 →