Heavy elements in urinary stones

被引:109
作者
Bazin, D.
Chevallier, P.
Matzen, G.
Jungers, P.
Daudon, M.
机构
[1] Hop Necker Enfants Malad, Lab Biochim A, APHP, F-75743 Paris 15, France
[2] Univ Paris 11, Phys Solides Lab, F-91405 Orsay, France
[3] Univ Paris 11, LURE, F-91405 Orsay, France
[4] CNRS, CRMHT, F-45071 Orleans 2, France
来源
UROLOGICAL RESEARCH | 2007年 / 35卷 / 04期
关键词
heavy metals; microfluorescence X; synchrotron radiation; calcium oxalate; calcium phosphate;
D O I
10.1007/s00240-007-0099-z
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The presence and role of heavy metals in urinary stones is debated. We investigated the distribution of trace heavy metals in 78 calculi of well-defined composition by means of microfluorescence X analysis using synchrotron radiation. Seven elements were identified, the most abundant being Zn and Sr which together accounted for 91 % of the heavy metal content of stones. The other heavy metals were Fe, Cu, Rb, Pb and Se. Zn and Sr were virtually confined to calcium-containing stones, whereas only trace amounts were found in uric acid or cystine stones. Among calcium stones, Zn and Sr were more abundant in calcium phosphate than in calcium oxalate stones and, in the latter, in weddellite than in whewellite stones. Fe, Cu and Rb were much less abundant and also found mainly in calcium stones. Ph was significantly less abundant than in previous studies, thus suggesting a rarefaction of Pb in the environment, and appreciable amounts of Se were found only in cystine stones. In conclusion, the pre-ponderance of Zn and Sr, both bivalent ions, in calciumcontaining stones suggests a substitution process of calcium by metal ions with similar charge and radius rather than a contribution of the metals to stone formation. Further studies are needed to examine the relationships between urine concentration in calcium or other solutes and the amount of Zn and Sr in calcium stones.
引用
收藏
页码:179 / 184
页数:6
相关论文
共 33 条
  • [1] Immobilization of uranium in contaminated sediments by hydroxyapatite addition
    Arey, JS
    Seaman, JC
    Bertsch, PM
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1999, 33 (02) : 337 - 342
  • [2] X-ray microprobes
    Chevallier, P
    Dhez, P
    Erko, A
    Firsov, A
    Legrand, F
    Populus, P
    [J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1996, 113 (1-4) : 122 - 127
  • [3] Daudon M, 2004, ANN BIOL CLIN-PARIS, V62, P379
  • [4] Changes in stone composition according to age and gender of patients:: a multivariate epidemiological approach
    Daudon, M
    Doré, JC
    Jungers, P
    Lacour, B
    [J]. UROLOGICAL RESEARCH, 2004, 32 (03): : 241 - 247
  • [5] DAUDON M, 1993, SCANNING MICROSCOPY, V7, P1081
  • [6] Daudon M., 2004, Nephron Physiol., V98, P31
  • [7] DURAK I, 1990, EUR UROL, V17, P243
  • [8] ANALYSIS OF CALCIUM, IRON, COPPER AND ZINC CONTENTS OF NUCLEUS AND CRUST PARTS OF URINARY CALCULI
    DURAK, I
    KILIC, Z
    SAHIN, A
    AKPOYRAZ, M
    [J]. UROLOGICAL RESEARCH, 1992, 20 (01): : 23 - 26
  • [9] Preliminary characterization of calcium chemical environment in apatitic and non-apatitic calcium phosphates of biological interest by X-ray absorption spectroscopy
    Eichert, D
    Salomé, M
    Banu, M
    Susini, J
    Rey, C
    [J]. SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 2005, 60 (06) : 850 - 858
  • [10] EICHERT D, 2004, KEY ENG MATER, V927, P254