Iron-catalyzed regio- and stereoselective ring opening of [2.2.1]- and [3-2.1]oxabicyclic alkenes with a Grignard reagent

被引：108

作者：

Nakamura, M ^{[1
]}

Matsuo, K ^{[1
]}

Inoue, T ^{[1
]}

Nakamura, E ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 08期

关键词：

D O I：

10.1021/ol034375b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Arylative and alkenylative ring-opening reactions of a [2.2.1]- or [3.2.1]oxabicyclic alkene with a Grignard reagent take place in the presence of a catalytic amount of iron(III) chloride and a stoichiometric amount of TMEDA to produce a highly substituted 3-cyclohexen-1-ol or 3-cyclohepten-1-ol in good yield with high regio- and stereoselectivity.

引用

页码：1373 / 1375

页数：3

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