Escape from host-antitumor immunity

被引：86

作者：

Pawelec, G

Zeuthen, J

Kiessling, R

机构：

[1] Univ Tubingen, Med Klin & Poliklin, Innere Med Abt 2,Sect Transplantat Immunol, Tubingen Ageing & Tumour Immunol Grp, D-72076 Tubingen, Germany

[2] Danish Canc Soc, Div Canc Biol, Dept Tumor Cell Biol, Copenhagen, Denmark

[3] Karolinska Inst, MTC, Stockholm, Sweden

来源：

CRITICAL REVIEWS IN ONCOGENESIS | 1997年 / 8卷 / 2-3期

关键词：

tumor antigen; immunosurveillance; tumor rejection; T-cell-mediated immunity;

D O I：

10.1615/CritRevOncog.v8.i2-3.10

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cells may express proteins recognizable by the individual's immune system as foreign because they are either tumor-specific or not expressed at high levels in normal tissues to which the host is tolerant. There is now much evidence that tumors can be immunogenic, that is, that they frequently express antigens in a form recognizable by the host immune system. This has been shown not only in experimental animals but also for spontaneously occurring human tumors. Tumors therefore may progress by evolving variants that can evade immune responses or by developing other strategies to "escape" the immune response. The purpose of this review is to consider the current status of knowledge concerning these different tumor escape strategies.

引用

页码：111 / 141

页数：31

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