Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity

被引：122

作者：

Carbone, FR ^{[1
]}

Belz, GT

Heath, WR

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 12期

关键词：

D O I：

10.1016/j.it.2004.09.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique phenotypic and functional characteristics. Although certain subsets migrate from peripheral non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that permanently reside within the lymph node. This Opinion describes this finding in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction.

引用

页码：655 / 658

页数：4

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