Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones

被引：25

作者：

Kuntz, Sandra ^{[1
,2
]}

Mazerbourg, Sabine ^{[1
,2
]}

Boisbrun, Michel ^{[3
,4
]}

Cerella, Claudia ^{[5
]}

Diederich, Marc ^{[5
,6
]}

Grillier-Vuissoz, Isabelle ^{[1
,2
]}

Flament, Stephane ^{[1
,2
]}

机构：

[1] Univ Lorraine, CRAN, UMR 7039, F-54506 Vandoeuvre Les Nancy, France

[2] CNRS, CRAN, UMR 7039, Vandoeuvre Les Nancy, France

[3] Univ Lorraine, SRSMC, UMR 7565, F-54506 Vandoeuvre Les Nancy, France

[4] CNRS, SRSMC, UMR 7565, F-54506 Vandoeuvre Les Nancy, France

[5] Hop Kirchberg, Lab Biol Mol & Cellulaire Canc, L-2540 Luxembourg, Luxembourg

[6] Seoul Natl Univ, Coll Pharm, Dept Pharm, Seoul 151742, South Korea

来源：

BIOCHEMICAL PHARMACOLOGY | 2014年 / 92卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Cancer; Glucose metabolism; 2-deoxyglucose; Thiazolidinediones; Warburg effect; ACTIVATED-RECEPTOR-GAMMA; TRAIL-INDUCED APOPTOSIS; SENSITIZES TUMOR-CELLS; BREAST-CANCER; PROSTATE-CANCER; DOWN-REGULATION; PPAR-GAMMA; IN-VITRO; TROGLITAZONE DERIVATIVES; LYMPHOBLASTIC-LEUKEMIA;

D O I：

10.1016/j.bcp.2014.07.021

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)gamma that were developed to treat type II diabetes. These compounds also display anticancer effects which appear mainly to be independent of their PPAR gamma agonist activity but the molecular mechanisms involved in the anticancer action are not yet well understood. Results obtained on ciglitazone derivatives, mainly in prostate cancer cell models, suggest that these compounds could act as ERMAs. In the present paper, we introduce how compounds like 2-deoxyglucose target the Warburg effect and then we discuss the possibility that the PPAR gamma-independent effects of various TZD could result from their action as ERMAs. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：102 / 111

页数：10

共 115 条

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Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death [J].