Microbial transformation of ginsenoside Rb1 by Rhizopus stolonifer and Curvularia lunata

被引：70

作者：

Dong, AL ^{[1
]}

Ye, M ^{[1
]}

Guo, HZ ^{[1
]}

Zheng, JH ^{[1
]}

Guo, D ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2003年 / 25卷 / 04期

基金：

中国国家自然科学基金;

关键词：

biotransformation; Curvularia lunata; ginsenoside; Rhizopus stolonifer;

D O I：

10.1023/A:1022320824000

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Of 49 microbial strains screened for their capabilities to transform ginsenoside Rb-1, Rhizopus stolonifer and Curvularia lunata produced four key metabolites: 3-O-[beta-D-glucopyranosyl-(1,2)-beta-D-glucopyranosyl]- 20-O-[beta-D-glucopyranosyl]-3beta,12beta, 20(S)-trihydroxydammar-24-ene (1), 3-O-[beta-D-glucopyranosyl-(1,2)-beta-D-glucopyranosyl]-20-O-[beta-D-glucopyranosyl]-3beta,12beta, 20(S)-trihydroxydammar-24-ol (2), 3-O-[beta-D- glucopyranosyl-(1,2)-beta-D-glucopyranosyl]-3beta,12beta, 20(S)-trihydroxydammar-24-ene(3), and 3-O-beta-D-glucopyranosyl- 3beta,12beta,20(S)-trihydroxydammar-24-ene(4), identified by TOF-MS, H-1- and C-13-NMR spectral data. Metabolites 1, 3 and 4 were from the incubation with R. stolonifer, and 1 and 2 from the incubation with C. lunata. Compound 2 was identified as a new compound.

引用

页码：339 / 344

页数：6

共 9 条

[1]

Bae EA, 2000, BIOL PHARM BULL, V23, P1481, DOI 10.1248/bpb.23.1481

[2]

Chen Xin, 1999, Acta Pharmaceutica Sinica, V34, P410

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