The structural biology of molecular recognition by vancomycin

被引：95

作者：

Loll, PJ ^{[1
]}

Axelsen, PH

机构：

[1] Univ Penn, Sch Med, Johnson Fdn Mol Biophys, Dept Pharmacol,Infect Dis Sect, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Johnson Fdn Mol Biophys, Dept Med,Infect Dis Sect, Philadelphia, PA 19104 USA

来源：

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE | 2000年 / 29卷

关键词：

glycopeptide antibiotics; molecular dynamics simulation; entropy-enthalpy compensation; cooperativity; allosterism;

D O I：

10.1146/annurev.biophys.29.1.265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vancomycin is the archetype among naturally occurring compounds known as glycopeptide antibiotics. Because it is a vital therapeutic agent used worldwide for the treatment of infections with gram-positive bacteria, emerging bacterial resistance to vancomycin is a major public health threat. Recent investigations into the mechanisms of action of glycopeptide antibiotics are driven by a need to understand their detailed mechanism of action so that new agents can be developed to overcome resistance. These investigations have revealed that glycopeptide antibiotics exhibit a rich array of complex cooperative phenomena when they bind target ligands, making them valuable model systems for the study of molecular recognition.

引用

页码：265 / 289

页数：25

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